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Description
SKP2 GST Tag Protein, HumanProduct Specification Species Human Synonyms FBXL1 Accession Q13309 Amino Acid Sequence Arg89 Leu424 with GST Tag at the N Terminus Expression System E. coli Molecular Weight 63kDa (Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag GST Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability
Product Specification
| Species | Human |
| Synonyms | FBXL1 |
| Accession | Q13309 |
| Amino Acid Sequence | Arg89-Leu424 with GST Tag at the N-Terminus |
| Expression System | E.coli |
| Molecular Weight | 63kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | GST Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Schulman BA, Carrano AC, Jeffrey PD, et al. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature. 2000;408(6810):381-386. |
Background
SKP2 (S-phase kinase-associated protein 2) is an F-box-containing substrate-recognition subunit of the SCFSKP2 E3 ubiquitin ligase complex (Cullin-1-SKP1-SKP2-Rbx1). Its N-terminal F-box docks onto SKP1, while C-terminal leucine-rich repeats (LRRs) capture phosphorylated targets. By catalysing K48-linked poly-ubiquitylation, SKP2 drives proteasomal degradation of a panel of tumour suppressors and cell-cycle brakes, including p27Kip1, p21Cip1, p57Kip2, FOXO1, BRCA2 and RASSF1A, thereby promoting G1/S progression, DNA replication and survival signalling.
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4.8 ★★★★★
Based on 458 reviews
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Product Reviews
★★★★★ 5
Smart, powerful and worth the price 👍
Color: Black, Size: X60 Max Ultra Complete, Color: Black, Size: X60 Max Ultra Complete
This robot vacuum has exceeded my expectations. One of my favorite features is how thin it is it reaches under furniture that my previous robot could never access. The suction is incredibly powerful and does an excellent job picking up pet hair, dust, and debris from both hard floors and rugs. The mopping function is surprisingly effective, especially with the hot-water cleaning that helps tackle dried-on spots and everyday messes. I’ve also noticed how intelligently it moves around the house, avoiding obstacles without constantly getting stuck. The self-cleaning dock takes care of most of the maintenance, which makes the whole experience much more convenient. Setup was straightforward, and the app gives plenty of customization options. Overall, it’s a reliable, hands-off cleaning solution that keeps my floors looking great with very little effort from me.
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Reviewed in the United States on May 31, 2026
★★★★★ 1
Don't toss mop pad holders after a pooptastrophie & take a pic or video for proof
Color: White, Size: X60 Max Ultra Complete
I’ve been using the DREAME X60 Max Ultra Complete Robot Vacuum and Mop for a while now, and it genuinely felt like a major upgrade from previous robot cleaners.
The first thing that stands out is the 35,000Pa suction power—it handles fine cat and dog hair, even on plush carpets. Compared to other models I've had, the cleaning performance is noticeably stronger and more consistent.
The ultra-thin 3.13-inch design is another big win. It reaches under most beds, sofas, and low furniture where dust usually accumulates. It takes some time to program these details into the vacuum.
I was very impressed by the fully automated system:
• Self-emptying dustbin
• Automatic water refilling
• Mop self-cleaning
This significantly reduces manual maintenance—you can go days (or longer) without needing to intervene. Until one Sunday evening, I decided to run the unit in the bathroom I share with my cats' automatic litter box, sight unseen. My cat pooped on the floor right in front of her litter box. Over the past two months, the unit has been good about avoiding wires, my black UGG slippers (the unit thought was an uncleanable mess), and my animals. As I was preparing dinner, I noticed the unit sounded a bit strange and clicky. Cat poo wafted through the air as I saw the unit flinging feces into the air and across the area in a sand-like spray. I thought the unit sucked up the poo, but it was mostly dispersed throughout the bathroom floor, baseboards, and walls. The poo was partially dry when the machine discovered it. By the time I discovered the machine, the mop pads and wheels were caked. I put on some gloves, pulled the mop pads off, tossed them in the trash, and proceeded to clean the machine carefully and gently for the next two hours. The next day, I called customer service, and when I asked for them to send me replacement mop pad holders, they said don't worry about it, we will send a new unit after you provide the info we request in an email. It wasn't until the next day that I got an email back asking for pictures and video of the pootastrophie. I didn't take a picture or video because I trusted that the machine caught it on video and labeled the poo as large particles or something. The next time I logged in, the history and video of Sunday night's ordeal were erased. I'm not sure if there was an update. I received an email today saying they don't have the mop pad holders; instead, they offered to give me more mop pads and dust bags. I can't use the mop function, which is half of the reason I got the unit.
**** Update Friday, May 8, 2026: My claim was escalated after I refused the extra mop pad holders and dustbags nix the mop pad holder. They are following through with replacing the unit and returning the pooptastrophy unit for testing. Will post updates.
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Reviewed in the United States on May 6, 2026
★★★★★ 5
Already impressed after the first few runs
Color: Black, Size: X60 Max Ultra Complete
I opened this almost immediately after it arrived because I’d been wanting to replace my older robot vacuum for a while. Setup was pretty straightforward and the app connected faster than I expected.
The first thing I noticed was how accurate the mapping is. It mapped my apartment surprisingly well on the first run and didn’t randomly bump into everything like my previous one did. Navigation feels smooth and organized instead of chaotic.
Cleaning performance has been really good so far too. It picked up a lot more dust and pet hair than I realized was on the floor, and the mopping feature actually leaves the floor looking fresh instead of just lightly wiping it.
The self-emptying and self-cleaning features are honestly the best part for me. I barely have to think about it once it starts running. Feels like one of those purchases that actually saves time every day.
So far I’m really happy with it and already wondering why I waited this long to get one.
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Reviewed in the United States on May 7, 2026
★★★★★ 4
Better after replacement
Color: White, Size: X60 Max Ultra Complete
I have tried to like it but it just keeps disappointing me. For the price I really expected to be able to handle my 1 floor apartment. It refuses to clean under my couches (they are 5” off the floor so enough space), it has mopped my carpet and it keeps getting lost. It couldn’t find the base and it was right in front of it for about an hour until I finally just manually put it back. I’ve only had it running for about a week and I’ve played with the settings and tried so many different things to get it to just throughly clean my floors. It is pretty and when it does clean it’s effective and it does work on my shag rug which is a feat. I just don’t trust it to work properly when I’m not home, which sucks.
Edit: Dreame reached out and tried to troubleshoot the vacuum. After the vacuum was still acting weird so they offered to replace it and a discount, which I will be taking advantage of. I really want it to work since it has powerful suction and 2 brushes. The brushes are truly tangle free, I didn’t find a single hair on the brushes after 2 weeks and I shed a lot. Plus it looks so pretty. I’ll give another update after the new vacuum.
Edit: The new vacuum is working much better. It cleaned better under my couch and has had to errors. It started to even clean even more thoroughly under the couch when I pinned up the fabric that's under the couch. I would suggest to do this so the sensors can more effectively see. I'm glad I gave it another chance.
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Reviewed in the United States on March 19, 2026
★★★★★ 5
Great value
Color: 14Pcs Eufy E25/E28/C28 Bags
These worked flawlessly with my eufy vacuum, no suction issues or anything. They seem to be just as durable, plus the same size as the name brand ones but at a fraction of the prize. It was very easy to use them. Just pop the old one out and pop this one in. Over all I’d say these are a great value for the money. Same size, same quality, much better value.
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Reviewed in the United States on May 30, 2026
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