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Description
RRM1 Recombinant Rabbit mAb (S-587-21)Product Specification Host Rabbit Antigen RRM1 Synonyms Ribonucleoside diphosphate reductase large subunit, Ribonucleoside diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RR1 Immunogen Synthetic Peptide Location Cytoplasm Accession P23921 Clone Number S 587 21 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM Reactivity Hu, Ms, Rt Predicted Reactivity Or Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | RRM1 |
| Synonyms | Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RR1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P23921 |
| Clone Number | S-587-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:100 | |
| ICFCM | 1:50 |
Background
Ribonucleotide reductase large subunit M1 (RRM1) is a rate-limiting enzyme of the DNA synthesis pathway, and is depended on for the conversion of ribonucleotides to dNTPs. Studies have shown that increased levels of RRM1 are associated with resistance to gemcitabine. RRM1 has also been reported to affect disease prognosis of pancreatic cancer. In fact, the meta-analysis for RRM1 demonstrated that high expression of RRM1 was significantly associated with worse overall survival. The clinical impact of RRM1 has been elucidated
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4.4 ★★★★★
Based on 2415 reviews
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Product Reviews
★★★★★ 5
Excellent!
Size: 22'' X 22''
Highly recommend this pad holder. Does an excellent job keeping the pad secure and in place. No more shredded pads since. Bonus: no leaks on the floor. It’s so practical and so helpful.
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Reviewed in the United States on March 1, 2026
★★★★★ 3
Pretty Good But Not Perfect!
Size: 28'' X 34''
I have been using two of these frames for my miniature poodle puppy for almost a month now and while they are useful, they could be improved. The size of the frames are great for our miniature size poodle puppy and the Amazon pads that fit the frames absorb well without leaking underneath. The grips on the bottom of the frame keep it in place so it does not slide across floor. The frame hinges in the center so you can easily carry it through doorways. I am in my 60's so it is nice to be able to carry it to my work table in order to change pads while standing up.
My 4 month old 10 pound puppy can make a dinner plate size circle of pee onto the pad first thing in the morning. 4 large pees are easily held by the pee pads before needing to change it but we prefer to change the pads more often for sanitary reasons. Not sure if you have a very large breed dog that these would work for you. Our puppy likes going on these without hesitation so they are comfortable for him to walk around on and turn to find just the right spot!
Compared to other brands I have looked at this is a great value for money and worth a try to help with potty training your pup. Our puppy sleeps in an X-pen inside of our home at night and when we are gone so these help with keeping the pads where we want them. We have two - one inside X-pen and one by door where we are training puppy to go outside.
These frames are nice in appearance and seem like they will last but they are a little awkward to use compared to another brand I purchased which was more durable and easier to change pad. I ended up with these because other brands do not offer such a large size (28 x 34).
Our main complaints about these frames are:
1. The top frame is hinged and a little wobbly to manuever over the edges of the pee pads. Another brand, while a bit smaller, has a solid one piece frame that goes over entire pad in one step. This frame requires a three step process of laying pad down, pulling edges out flat and placing one side of frame down and then repeating on other side. There is usually a bit of adjustment that needs to be done and so requires opening and closing the frame again for adjustments.
2. The Amazon pee pads that fit this frame hold the pee well without leaking but have very thin tissue paper like edges (blue) that do not extend out far enough to make capturing the edges of the pee pad under the frame very easy to maneuver. It would be a game changer if the pads were made at least 1" bigger around length and width so edges are firmly held in place.
3. Our tiny 10 pound poodle pup is able to easily dig out edges of pad and tear it up. Not as bad as a loose pad by any means, but blue edges are exposed at side centers where frame hinges and there is no cover of edges (unlike a one piece frame) and the blue color seems to attract him. He can dig and loosen pad on any side because there is no way to hide and hold down all of the blue edges of pee pad.
I am still using these to potty train and, as I said earlier, these are way better than loose pee pads. I may shop for even larger size pee pads in the future to better lock down all of the edges without so much difficulty.
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Reviewed in the United States on May 5, 2026
★★★★★ 4
Good product for dog training.
Size: 22'' X 22''
Work for the most part. Dogs will chew on it so wipe it down with dawn dish soap. Hard to clean where it clips down.
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Reviewed in the United States on March 13, 2026
★★★★★ 5
Saving My Floors
Size: 28'' X 34'', Size: 28'' X 34''
Omg, what a game changer. My pups like to destroy the pads whenever they get the chance to. With this they still try but never succeed. I will say that it can be a little sturdier as the handles are a little flimsy, but I manage and it does the job. It's very easy to use when I change the pads and I use 2 pads for coverage. I just placed it where I usually place their pads and it fits right in the spot. They are trained to go outside but on rainy days this comes in handy. To save my floors it's definitely worth the money spent.
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Reviewed in the United States on April 26, 2026
★★★★★ 5
Works great
Size: Small
Perfect addition to my puppies pen. Love that she doesn't try to eat the pee pads. Easy clean up. Perfect 👌
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Reviewed in the United States on May 9, 2026