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Description
Bax Recombinant Rabbit mAb (S-2603-124)Product Specification Host Rabbit Antigen Bax Synonyms Apoptosis regulator BAX Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Mitochondrion Accession Q07813 Clone Number S 2603 124 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Mk Positive Sample HEK 293, NIH 3T3, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | Bax |
| Synonyms | Apoptosis regulator BAX |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Mitochondrion |
| Accession | Q07813 |
| Clone Number | S-2603-124 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Mk |
| Positive Sample | HEK-293, NIH/3T3, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Mk |
| IHC-P | 1:1000-1:5000 | Hu, Ms |
Background
Bax is a pro-apoptotic member of the Bcl-2 protein family that localizes to the cytosol of healthy cells but, upon activation by developmental death cues or intracellular stress such as DNA damage, undergoes conformational change and translocates to the outer mitochondrial membrane where it oligomerizes to form pores that permeabilize the membrane, thereby releasing cytochrome c and other apoptogenic factors into the cytosol to trigger the caspase cascade and ultimately apoptosis.
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